Optical Coherence Tomography (OCT) is a novel 3D-imaging modality, however, there is limited research using OCT to study antiarrhythmics. An OCT drosophila model was developed for live non-invasive analysis of cardiovascular disease and pharmaceutical testing. With extensive drug delivery optimization, the effects of Ca²?, K?, and Na? channel blockers were observed on 216 samples using Segmentation/Python algorithms. Combining chemical therapeutics with optics yields novel uses in cardiac imaging and optogenetic pacing.This model is an effective way to analyze the physiological effects of drugs on the cardiovascular system before experimentation on mammalian species, thus reducing the cost and time of drug development by quickly identifying experimental molecules with cardiotoxic effects.

Contestants

Rhea Malhotra